Haplotype phasing after joint estimation of recombination and linkage disequilibrium in breeding pop

• 作 者: Luis Gomez-Raya Amanda M Hulse
• 机 构: DepartamentodeMejoraGen&,#233,ticaAnimal,nyTecnologiaAgrariayAlimentaria（INIA）,InterdisciplinaryP
• 出 处: 畜牧与生物技术杂志：英文版
• 发表日期: 2014年1期
• 关键词: 连锁不平衡 联合估计 重组率 单倍型 MONTE-CARLO模拟 育种群体 单核苷酸多态性 计算机模拟 Breeding Haplotype phasing
• 基金项目: support from a Marie Curie International Reintegration Grant from the European Union,project no.PIRG08-GA-2010-277031 “SelectionForWelfare”,LGR and WMR acknowledge support from project AGL2012-39137

A novel method for haplotype phasing in families after joint estimation of recombination fraction and linkage disequilibrium is developed. Results from Monte Carlo computer simulations show that the newly developed E.M.algorithm is accurate if true recomb