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宫内胎儿发育迟缓(IUGR)是导致围产期胎儿死亡和发病的主要原因之一。巨噬细胞集落刺激因子(M-CSF)被定义为造血生长因子,能诱导单核/巨噬细胞和粒细胞的生长、分化及延长其存活。M-CSF在胎盘的发育中亦发挥重要作用,其mRNA表达于滋养层及绒膜羊膜基质。羊水中M-CSF水平随妊娠周数显著增高。提示M-CSF是人胎盘生长和分化的调节因子之一,羊水中M-CSF水平与胎盘
Intrauterine fetal growth retardation (IUGR) is one of the major causes of perinatal fetal death and morbidity. Macrophage colony-stimulating factor (M-CSF) is defined as a hematopoietic growth factor that induces the growth, differentiation and prolongation of monocyte / macrophage and granulocyte survival. M-CSF also plays an important role in the development of the placenta, whose mRNA is expressed on the trophoblast and the human amniotic membrane. Amniotic fluid M-CSF levels significantly increased with the number of gestational weeks. Tip M-CSF is one of the regulatory factors of human placenta growth and differentiation, amniotic fluid M-CSF levels and placenta