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为了探讨胃液氨含量与幽门螺杆菌（Ｈｐ）相关性胃炎炎症程度的关系，对３９例Ｈｐ（＋）及２３例Ｈｐ（－）慢性胃炎患者胃液氮含量进行测定，同时对其胃窦粘膜的炎症程度用中性粒细胞（ＰＭＮ）及单个核细胞（ＭＮ）计数方法予以评价。研究发现：Ｈｐ（＋）胃炎组胃液氨含量（８４．１０±３３．０７ｍｇ／Ｌ）显著高于Ｈｐ（－）胃炎组（２２．５９±１３．１２ｍｇ／Ｌ）（Ｐ＜０．０１），ＰＭＮ及ＭＮ计数在Ｈｐ（＋）胃炎组显著高于Ｈｐ（－）胃炎组，胃液氨含量与ＰＭＮ计数成正相关（ｒ＝０．４８，Ｐ＜０．０５），而与其ＭＮ计数无相关性。本研究表明胃液氨含量与Ｈｐ相关性胃炎的炎症程度关系密切，Ｈｐ的尿素酶产物－氨在Ｈｐ致胃粘膜损伤及炎症活动性中可能起着重要作用。
In order to investigate the relationship between the ammonia content of gastric juice and the degree of inflammation associated with Helicobacter pylori (Hp) -related gastritis, gastric juice nitrogen concentration was measured in 39 Hp (+) and 23 Hp (-) chronic gastritis patients, The degree of inflammation was evaluated by counting neutrophils (PMN) and mononuclear cells (MN). The results showed that ammonia content in gastric juice of Hp (+) gastritis group was significantly higher than that of Hp (-) gastritis group (84.10 ± 33.07mg / L) (22.59 ± 13.12mg / L) (P <0.01) , PMN and MN counts in Hp (+) gastritis group were significantly higher than those in Hp (-) gastritis group. The ammonia content in gastric juice was positively correlated with PMN count (r = 0.48, P <0.05), but not with MN count Sex. This study showed that ammonia content in gastric juice is closely related to the degree of inflammation of Hp-related gastritis. Hg urease product, ammonia, may play an important role in gastric mucosal injury and inflammatory activity induced by Hp.