Mismatch repair genes （hMLH1, hPMS1, hPMS2, GTBP／hMSH6,hMSH2） in the pathogenesis of hepatocellular

• 作 者: AbdeI-RahmanN.Zekri GelaneM.Sa
• 机 构: VirologyandImmunologyUnit,BiochemistryDepartment,PathologyDepartment,TropicalMedicineDepartment
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2005年20期
• 关键词: 错配基因 基因修复 HMLH1 hPMS1 hPMS2 GTBP/hMSH6 HMSH2 肝细胞癌 病理机制 Hepatocellular carcinoma

AIM: DNA misrnatch repair (MMR) is an impotent mechanism for maintaining fidelity of genomic DNA. Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1,