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目前国内外对吡喹酮治疗包虫病的研究尚少,且对其疗效存在争议。现已证明,在口服吡喹酮治疗人体肝、肺包虫病时,药物确能进入包虫囊内,但其浓度很低。本文在此基础上,进一步对上述25例术前服用吡喹酮治疗的肝、肺包虫病患者,于手术时取其体内棘球蚴进行电镜观察,研究药物对包虫囊肿生发层和原头蚴体表超微结构的影响,同时还观察了原头蚴活力及死亡率;另设未服药组作为对照(肺包虫24例,肝包虫
At present, there are still few researches on praziquantel in the treatment of hydatid disease both at home and abroad, and its efficacy is controversial. It has been shown that in the oral praziquantel treatment of human liver, pulmonary echinococcosis, the drug can indeed enter the hydatid disease capsule, but its concentration is low. On this basis, further on the 25 cases of praziquantel treatment of liver and pulmonary echinococcosis patients before operation, take their echinococcus granulosus observation by electron microscopy, the drug hydatid cyst germinal layer and the original Head and neck larvae ultrastructural effects, but also observed the original primary cercariae vitality and mortality; another set of non-medication group as a control (pulmonary hydatid 24 cases, liver hydatid