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采用免疫组织化学方法研究了产后授乳和中断授乳的雌性大鼠下丘脑内促性腺激素释放激素(GnRH)阳性神经元和神经纤维的密度和染色反应的动态变化。在哺乳的第3天,将仔鼠去除,在中断授乳后的第1天～4天,下丘脑内侧隔核、视前内侧区和Broca斜角带内的GnRH阳性神经元胞体的反应强度明显高于继续授乳组。在正中隆起和终板血管器的GnRH阳性纤维密度和染色强度也比授乳组明显增加。结果表明:中断授乳的母鼠下丘脑内GnRH分泌神经元激素的合成和释放功能均明显增强;相反,授乳对下丘脑内GnRH神经元的合成和释放激素的功能有抑制作用。
The dynamic changes of density and staining of gonadotropin-releasing hormone (GnRH) -positive neurons and nerve fibers in the hypothalamus of postnatal and interrupted lactating female rats were studied by immunohistochemistry. On day 3 of lactation, the offspring were removed, and the intensity of GnRH positive neurons in the medial hypothalamic medial septum, the anteromedial medial area and Broca’s bevel zone were significantly increased from days 1 to 4 after interruption of lactation Higher than continue lactation group. The density and staining intensity of GnRH positive fibers in the midlift and endplate vessels were also significantly increased compared to the lactation group. The results showed that the synthesis and release of GnRH-secreting neurons in the hypothalamus of the interrupted lactating maternal rats were significantly enhanced. In contrast, lactation inhibited the synthesis and release of the hormones in the hypothalamus GnRH neurons.