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AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions.
AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis. METHODS In 42 cirrhotic patients and 20 subjects, the following fecal proteins were measured by enzyme-linked immunosorb6nt assay: albumin (Alb), transferrin (Tf), and al- antitrypsin a, -AT) as a marker for intestinal protein l0ss, hemoglobin (Hb) for bleeding, PMN-eIastase for intestinal inflammation, and secretory lgA for intestinalimmunity.RESULTS The fecal concentrations of Hb, Alb, Tf, al- AT, and PMN’eIastase (6%), and 1l (26%) cases among 42 patients, respectivly. F6cal concentration of secretory IgA was created in 7 (17%), 8 ) of 42 patients. However, these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significant Iy decreased in patients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss. CONCLUSION These findings suggest that: rob6sides the weIl ’kn own pathological conditions, Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunity? Found in cirrhotic patients, @ intestinal protein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients, since it may contribute to or cause intestinal protein Ioss and oth6r various pathologicalconditions.