【摘 要】
：
Objective: To observe the immediate effect and safety of Shexiang Tongxin dropping pills (麝香通心滴丸, STDP) on patients with coronary slow flow (CSF), and furthermore, to explore new evidence for the use of Chinese medicine in treating ischemic chest pain. Me
【机 构】
：
Department of Cardiovascular Medicine, Ningbo Hosptial of Zhejiang University, Ningbo First Hospital
论文部分内容阅读
Objective: To observe the immediate effect and safety of Shexiang Tongxin dropping pills (麝香通心滴丸, STDP) on patients with coronary slow flow (CSF), and furthermore, to explore new evidence for the use of Chinese medicine in treating ischemic chest pain. Methods: Coronary angiography (CAG) with corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) was applied (collected at 30 frames/s). The treatment group included 22 CSF patients, while the control group included 22 individuals with normal coronary?ow. CSF patients were given 4 STDP through sublingual administration, and CAG was performed 5 min after the medication. The immediate blood ?ow frame count, blood pressure, and heart rate of patients before and after the use of STDP were compared. The liver and kidney functions of patients were examined before and after treatments. Results: There was a signi?cant difference in CTFC between groups (P<0.05). The average CTFC values of the vessels with slow blood ?ow in CSF patients were, respectively, 49.98±10.01 and 40.42±11.33 before and after the treatment with STDP, a 19.13％ improvement. The CTFC values (frame/s) measured before and after treatment at the left anterior descending coronary artery, left circumflex artery, and right coronary artery were, respectively, 48.00±13.32 and 41.80±15.38, 59.00±4.69 and 50.00±9.04, and 51.90±8.40 and40.09±10.46, giving 12.92％, 15.25％, and 22.76％ improvements, respectively. The CTFC values of vessels with slow ?ow before treatment were signi?cantly decreased after treatment (P<0.05). There were no apparent changes in the heart rate, blood pressure, or liver or kidney function of CSF patients after treatment with STDP (all P>0.05). Conclusions: The immediate effect of STDP in treating CSF patients was apparent. This medication could signi?cantly improve coronary ?ow without affecting blood pressure or heart rate. Our ?ndings support the potential of Chinese medicine to treat ischemic chest pain.
其他文献
Objective:To investigate the neuro-protective effects of Acanthopanax senticosus Harms (EAS)on mesencephalic mitochondria and the mechanism of action,using a mouse model of Parkinson\'s disease (PD).Methods:The chemical fingerprint analysis of the extra
Objective: To evaluate the preventive effect of salvianolate (Sal B) onglucose metabolism disorders of dimethylnitrosamine (DMN)-induced cirrhotic rats. Methods: Fifty-five Wistar rats were randomly divided into a controlgroup (n=10) and a cirrhoticgroup
Objective:To investigate whether ginsenoside-Rb1 (Gs-Rb1) improves the CoCl2-induced autophagy of cardiomyocytes via upregulation of adenosine 5\'-monophosphate-activated protein kinase (AMPK) pathway.Methods:Ventricles from 1-to 3-day-old Wistar rats w
Objective:To investigate the effects and safety of catgut embedding on alleviating insomnia.Methods:Totally 510 patients with insomnia were divided into 5 Chinese medicine (CM) syndrome types:Xin (Heart) and Pi (Spleen) deficiency,yin deficiency with exce
Objective:To investigate the important diagnostic indicators for blood stasis syndrome (BSS) in patients of childbearing age with gynaecological diseases.Methods:A partial least squared-discriminant analysis (PLS-DA) were applied to BSS symptoms data of p
Objective:To evaluate the effectiveness and safety of Chinese medicine (CM) for Idiopathic pulmonary fibrosis (IPF) patients.Methods:To screened relevant articles,PubMed,Cochrane Library,Excerpta Medica Datase (EMBASE),China National Knowledge Infrastruct
Objective:To detect the anticoagulation and antiplatelet effects of different concentrations of puerarin,heparin sodium and tirofiban hydrochloride on the blood samples of healthy volunteers by Sonoclot coagulation and platelet function analyzer.Methods:P
Definition of Contrast-Induced NephropathyrnContrast-induced nephropathy (CIN),also called contrast-induced acute kidney injury (CI-AKI),is a leading cause of hospital-acquired AKI as a possible complication of intravenous contrast media administration.(1
Background:Microvascular complications in type 2 diabetes (T2DM),including diabatic retinopathy (DR),diabetic kidney disease (DKD),diabetic peripheral neuropathy (DPN) are the leading causes of visual loss,end-stage renal disease or amputation,while the c
Public health is the science and art of preventing disease,prolonging life and prompting physical and mental health through evaluation,policy development and sanitary measures.The development of public health has become an important part of health care re