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目的：对新生儿静脉滴注头孢呋辛进行药物动力学研究，了解该药在新生儿体内的代谢特点及对新生儿的脑膜通透性。方法：７名新生儿静脉滴注头孢呋辛２５ｍｇ／ｋｇ，进行药物动力学参数测定（取血１００μｌ）；８名化脓性脑膜炎新生儿静脉滴注后２ｈ取脑脊液（ＣＳＦ，５０μｌ），测定药物浓度。结果：静脉滴注后峰浓度达７５．２２±１２．９７ｍｇ／Ｌ，１２ｈ药物浓度为６．９５±１．７０ｍｇ／Ｌ，药物消除半衰期为３．７０±０．３７ｈ，表观分布容积为０．３４±０．０５Ｌ／ｋｇ，清除率为０．０７９±０．０１６Ｌ／（ｋｇｈ）。８名化脓性脑膜炎新生儿静滴后２ｈ脑脊液浓度为４．９５±２．８ｍｇ／Ｌ，为同期血浓度的１１％±６．１％。结论：头孢呋辛在新生儿体内维持有效浓度时间较长，脑膜通透性较强，适合新生儿抗感染使用，用药间隔应为１２ｈ
OBJECTIVE: To study the pharmacokinetics of cefuroxime in neonates by intravenous infusion and to understand the metabolic characteristics of the drug in the newborn and the permeability of the brain to the neonate. Methods: Seven newborns were given cefuroxime 25 mg / kg intravenously, and their pharmacokinetic parameters were determined (100 μl of blood was taken). Eight neonates with purulent meningitis were given cerebrospinal fluid (CSF, 50 μl) Drug concentration. Results: After the intravenous infusion, the peak concentration reached 75.22 ± 12.97mg / L, the drug concentration at 12h was 6.95 ± 1.70mg / L, the elimination half-life was 3.70 ± 0.37h, the apparent volume of distribution was 0.34 ± 0.05L / kg, the clearance rate was 0.079 ± 0.016L / (kgh). 8 cases of purulent meningitis 2 hours after intravenous infusion of cerebrospinal fluid concentration was 4.95 ± 2.8mg / L, for the same period the blood concentration of 11% ± 6.1%. Conclusion: Cefuroxime in the neonatal body to maintain a valid concentration for a long time, strong permeability of the meninges, suitable for neonatal anti-infective use, medication interval should be 12h