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目的探讨氯沙坦联合贝那普利的方法治疗糖尿病肾病的临床疗效。方法选择在本院就诊的符合糖尿病肾病患者116例。随机分成观察组和对照组两组,两组均施行糖尿病教育、控制饮食、适当运动和常规药物控制血糖。对照组在常规治疗的基础上使用贝那普利10mg,1次/d。观察组在对照组的基础上联用氯沙坦50mg,1次/d。3周为1疗程,疗程结束后评定疗效。结果观察组临床总有效率为89.66%高于对照组的临床总有效率58.62%,具有显著差异(P<0.01),治疗期间未发现患者有不良反应。结论采用氯沙坦联合贝那普利的方法治疗糖尿病肾病患者疗效佳,而且具有良好的安全性及耐受性,建议临床进一步推广。
Objective To investigate the clinical efficacy of losartan and benazepril in the treatment of diabetic nephropathy. Methods 116 patients with diabetic nephropathy were selected in our hospital. Randomly divided into observation group and control group, two groups were administered diabetes education, diet, exercise and conventional drugs to control blood sugar. The control group received benazepril 10 mg once daily on the basis of routine treatment. Observation group in the control group based on the combination of losartan 50mg, 1 / d. 3 weeks for a course of treatment, after the assessment of curative effect. Results The total clinical effective rate was 89.66% in the observation group and 58.62% in the control group, with significant difference (P <0.01). No adverse reactions were found in the treatment group. Conclusion Losartan combined with benazepril treatment of diabetic nephropathy patients with good effect, and has good safety and tolerability, it is recommended to further promote the clinical.