论文部分内容阅读
目的探讨解整合素-金属蛋白酶(ADAM)33 mRNA在慢性阻塞性肺病(COPD)患者中的表达。方法采用半定量RT-PCR的方法检测COPD患者静脉血中ADAM33 mRNA表达。结果 COPD组ADAM33 mRNA阳性表达率及表达水平明显高于正常照组,COPD急性加重期ADAM33 mRNA阳性表达率及表达水平均高于稳定期,有统计学意义。COPD患者ADAM33 mRNA表达水平与FEV1/FVC值呈负向直线相关。结论 ADAM33 mRNA表达上调可能与慢性阻塞性肺疾病病情相关。
Objective To investigate the expression of integrin - metalloproteinase (ADAM) 33 mRNA in patients with chronic obstructive pulmonary disease (COPD). Methods The expression of ADAM33 mRNA in venous blood of COPD patients was detected by semi-quantitative RT-PCR. Results The positive expression rate and expression level of ADAM33 mRNA in COPD group were significantly higher than those in normal control group. The positive expression rate and expression level of ADAM33 mRNA in COPD group were significantly higher than those in stable phase. ADAM33 mRNA expression levels in COPD patients were negatively correlated with FEV1 / FVC values. Conclusion The up-regulation of ADAM33 mRNA expression may be associated with chronic obstructive pulmonary disease.