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自 1 979年第 1个氟喹诺酮类药物诺氟沙星问世以来 ,相继合成了为数众多的衍生物〔1〕。该类药物以其高效、广谱等优点成为发展最为迅速的化学合成抗菌药物 ,日益受到临床医生的青睐 ,随着应用的增多 ,不良反应也时见报道 〔2〕。本文主要就诺氟沙星 ( FPA)、环丙沙星( CPFX)、
A large number of derivatives have been synthesized since the first fluoroquinolone norfloxacin in 1979 [1]. Such drugs with its high efficiency, broad-spectrum advantages such as the fastest-growing chemical synthesis of antibacterial drugs, increasingly favored by clinicians, with the application of more and more adverse reactions are also reported (2). This article mainly on norfloxacin (FPA), ciprofloxacin (CPFX),