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目的 探讨组织因子(TF)在人肝细胞肝癌(HCC)组织中的表达与肿瘤组织侵袭转移之间的关系.方法 对50例HCC及相应正常肝组织标本进行TF和CD34免疫组织化学EnVision~(TM)法检测.结果 (1)HCC中TF阳性表达率为62%,MVD值为(51.14±24.97),明显高于正常肝组织中的6%和(18.70±6.35).HCC中TF阳性组MVD值高于阴性组(P＜0.05).(2)HCC中TF的表达与患者静脉浸润、肝内外转移、包膜无或不完整有关(P＜0.05),Cox模型提示TF的表达足影响HCC患者总生存率的独立因素之一.结论 TF可能参与HCC侵袭转移,可作为评估HCC患者预后参考指标.“,”Objective To investigate the relationship of tissue factor(TF)expression and angiogenesis of hepatocellular carcinoma(HCC).Methods The expressions of TF and CD34 in 50 specimens of HCC and corresponding normal liver tissue were detected by EnVision~(TM) immunohistochemistry.Results Positive rates of TF and mierovessel density(MvD)in HCC were higher than those in normaIliver tissue[62% vs.6%and(51.14±24.97)vs.(18.70±6.35)](P＜0.05).MVD of HCC was significantly higher in TF-positive group than that in TF-negative group (P＜0.05).TF expression was correlated to vein invasion,intrahepatic metastasis,and the tumor without envelope(P＜0.05).Cox regression analysis showed that TF was an independent prognositic factor of HCC.Conclusion Overexpression of TF relates with metastasis and invasion of HCC.TF expression may be taken as a prognostic indicator in patients with HCC.