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目的观察羟氯喹治疗系统性红斑狼疮(SLE)皮疹的疗效。方法选择87例SLE患者,随机分成羟氯喹组、非羟氯喹组。羟氯喹组49例,口服羟氯喹400mg,2次/d及醋酸泼尼松;非羟氯喹组38例,仅使用醋酸泼尼松治疗,疗程4周。结果观察治疗有效率:羟氯喹组95.92%,非羟氯喹组81.58%,二组疗效比较差异无统计学意义(P>0.05),炎性指标血沉(ESR)及补体C3,治疗后二者差异有统计学意义(P<0.05)。结论加用羟氯喹治疗SLE皮肤损害,与单纯使用糖皮质激素治疗相比,加用羟氯喹组有效率高,监测炎症指标ESR及补体C3恢复较好,不良反应少见。
Objective To observe the efficacy of hydroxychloroquine in the treatment of systemic lupus erythematosus (SLE) rash. Methods 87 patients with SLE were randomly divided into hydroxychloroquine group and non-hydroxychloroquine group. 49 cases of hydroxychloroquine, oral hydroxychloroquine 400mg, 2 times / d and prednisone acetate; non-hydroxychloroquine 38 cases, only the use of prednisone acetate treatment, the course of 4 weeks. Results The effective rate of treatment was 95.92% in hydroxychloroquine group and 81.58% in non-hydroxychloroquine group, there was no significant difference between the two groups (P> 0.05), ESR and C3, There was statistical significance (P <0.05). Conclusions Compared with simple glucocorticoid therapy, hydroxychloroquine plus hydroxychloroquine plus hydroxychloroquine is more effective in treating skin lesions of SLE. ESR and complement C3 recovery are better, and adverse reactions are rare.