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再生障碍性贫血(再障)是以骨髓增生低下、全血细胞减少为特征的一种血液病。再障可由某些化学药物、感染和放射等因素损害骨髓而致。但大多数病例的病因尚不明确,推测可能是一种多病因的综合征。关于再障的发病机制一般从三方面考虑,即干细胞缺乏或缺陷,微环境异常和起调节作用的细胞和因子异常。近几年来,临床和实验研究都表明免疫系统失调可能与再障发病有关。淋巴细胞和免疫系统在调节造血中的作用以及免疫抑制造血在再障发病机制中的可能作用,引起
Aplastic anemia (aplastic anemia) is a hematological disorder characterized by low myeloproliferation and pancytopenia. Aplastic anemia can be caused by certain chemical drugs, infection and radiation damage to bone marrow and other factors. However, the etiology of most cases is not clear, suggesting that it may be a multi-etiological syndrome. On the pathogenesis of aplastic anemia generally from three aspects, namely, lack or defect stem cells, microenvironment abnormalities and regulatory cells and factors that play an abnormal. In recent years, clinical and experimental studies have shown that immune system disorders may be related to the pathogenesis of aplastic anemia. The role of lymphocytes and the immune system in the regulation of hematopoiesis and the possible role of immunosuppressive hematopoiesis in the pathogenesis of aplastic anemia, causing