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本文评价10例(男8,女2)慢性严重主动脉瓣关闭不全病人静注肼苯哒嗪(hydralazine)的效果,并讨论其改善心脏功能的机制。用药后平均动脉压降低(P<0.025),心率增加(P<0.005),平均肺动脉压及平均肺动脉楔状压减低(无显著性差异),左室舒张末期压降低(P<0.05),全身血管阻力自1,264mmHg 减低至710mmHg,心脏指数增加76%,每搏容量指数增加49%,左室舒张末期容量减少(自208ml/M~2降至190ml/M~2,P<0.05),收缩末期容量减少(自101ml/m~2降至82ml/
This article evaluates the effect of hydralazine in 10 patients (male 8, female 2) with chronic severe aortic regurgitation and discusses its mechanism of improving cardiac function. Mean arterial pressure decreased (P <0.025), heart rate increased (P <0.005), mean pulmonary arterial pressure and mean pulmonary wedge pressure decreased (no significant difference), left ventricular end diastolic pressure decreased (P < The resistance decreased from 1,264 mmHg to 710 mmHg, the cardiac index increased by 76%, the stroke volume index increased by 49%, the left ventricular end diastolic volume decreased (from 208ml / M ~ 2 to 190ml / M ~ 2, P < Capacity reduction (from 101ml / m ~ 2 to 82ml /