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目的评估胎儿纤维连接蛋白(fFN)水平对临床诊断孕妇发生早产的预测价值。方法选择产科门诊2016年1月—2017年1月期间先兆早产孕妇135例,分别取阴道后穹窿分泌物进行fFN定量和定性检测,阳性患者辅以超声测量宫颈长度,观察其妊娠结局;分析fFN定量与定性检测的结果相关性和临床一致性。结果平行比较二种fFN定量和定性检测产品测定135例孕妇,阳性符合率为100.00%,阴性符合率为98.9%;47例fFN阳性患者检后1周内和2周内的早产发生率均显著高于88例阴性患者(P<0.05);fFN阳性人群中,26例宫颈长度异常者(≤3cm),检后2周内早产发生率76.9%,显著高于宫颈长度正常者(>3cm,4.8%,P<0.05)。结论开展fFN检测对于高危孕产妇的早产预测具有重要意义,且具备了较好的临床实施条件。
Objective To evaluate the predictive value of fetal fibronectin (fFN) levels in the diagnosis of preterm birth in clinically diagnosed pregnant women. Methods 135 cases of threatened preterm labor during January 2016 to January 2017 in gynecological clinic were selected for quantitative and qualitative detection of fFN in vaginal vault secretions. The positive patients were examined with ultrasound to measure the cervical length and observe the pregnancy outcome. The fFN Quantitative and qualitative detection of the correlation and clinical consistency. Results The results showed that the positive coincidence rate was 100.00% and the negative coincidence rate was 98.9%. The positive rate of preterm birth was significantly higher in 47 cases of fFN positive patients within 1 week and 2 weeks 26 cases with abnormal cervical length (≤3cm) in fFN positive group, the incidence of preterm birth was 76.9% within 2 weeks after the test, which was significantly higher than those with normal cervical length (> 3cm, 4.8%, P <0.05). Conclusion The detection of fFN is of great significance for the prediction of preterm birth in high-risk pregnant women, and has good clinical implementation conditions.