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目的 :评价并比较伊曲康唑 2种短程疗法治疗角化型手癣的临床疗效、真菌学疗效及安全性。方法 :将 45例患者分为 1周疗法组和 2周疗法组。 1周疗法组给予伊曲康唑 2 0 0mgBid ,服用 7d ;2周疗法组给予伊曲康唑 2 0 0mgQd ,服用 1 4d。在服药前及停药后第 2周及第 4周进行临床症状和体征观察及真菌学镜检及培养。在服药前及停药第 4周时进行肝功能检查。以停药第 4周时的结果作为观察疗效的标准。结果 :1周疗法组在停药第 4周时的临床痊愈率为 82 6% ,总有效率为 95 6% ,真菌学治愈率为 95 6%。 2周疗法组在停药第 4周时的临床痊愈率为 81 8% ,总有效率为 90 9% ,真菌学治愈率为 95 4%。 2组间差异不显著(P >0 0 5)。 2组各有 2例患者出现轻度副作用 ,均未见严重不良反应。结论 :伊曲康唑的 2种短程疗法治疗角化型手癣均有效 ,且具有良好的安全性。 1周疗法方案具有疗程更短 ,患者的依从性及耐受性更好的优点 ,因此主张在临床推广使用
Objective: To evaluate and compare the clinical efficacy, the mycological efficacy and safety of two short-range treatments of itraconazole in the treatment of keratosis. Methods: 45 patients were divided into 1 week therapy group and 2 weeks therapy group. The patients in the 1-week therapy group were given itraconazole 200 mg Bid for 7 days. The patients in the 2-week therapy group were given itraconazole 200 mg Qd for 14 days. Clinical symptoms and signs and fungal microscopic examination and culture were performed before medication and 2 weeks and 4 weeks after drug withdrawal. Liver function tests were performed before medication and at the 4th week of withdrawal. To stop the first 4 weeks of the results as a standard observation of efficacy. Results: The clinical cure rate in the first week of treatment was 82.6% at the 4th week, the total effective rate was 95.6%, and the cure rate of mycology was 95.6%. In the 2-week treatment group, the clinical cure rate was 81.8% at the 4th week of withdrawal, the total effective rate was 90.9% and the cure rate of mycology was 95.4%. There was no significant difference between the two groups (P> 0.05). Two patients in each group had mild side effects, and no serious adverse reactions were seen. Conclusion: Itraconazole two kinds of short-course treatment of keratosis type ringworm are effective, and has good safety. The 1-week regimen has the advantages of shorter duration of treatment, better patient compliance, and better tolerability, and therefore advocates its use in clinical settings