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我省木防已[Cocculus trilobus(Thunb)De Candople]分布于秦岭和巴山山区,产量较大,我们从陕西产木防己中分离出生物碱,制成碘化甲基木防己碱,并配制成注射剂。经药理实验对横纹肌具有松弛作用;其肌松作用比箭毒碱强1.4倍(P<0.01)且两者之间具协同作用。本品尚具有降压、镇痛作用,试用于临床治疗高血压、风湿痛等,效果较显著。一、木防己总碱的分离1.称取本品干燥生药10公斤,加入75%乙醇五倍量,加热回流四次,每次二小时。过滤,滤液回收乙醇至无醇味。浓缩水溶液体积为10立升,用5%盐酸调节PH2.0—2.5放置,析出沉淀滤去。用乙醚振摇数次,脱脂。
Our province, Cocculus trilobus (Thunb) De Candople, is distributed in the Qinling and Bashan mountainous regions, and the yield is relatively large. We isolated the alkaloids from the wood grown in Shaanxi and made iodomethyltetracycline iodide and formulated it. injection. The pharmacological experiment had a relaxing effect on striated muscle; its muscle relaxation was 1.4 times stronger than that of streptozotocin (P<0.01) and there was a synergistic effect between the two. This product still has antihypertensive and analgesic effects. It has been used in clinical treatment of hypertension, rheumatic pain, etc. The effect is significant. I. Separation of Alkaloids from Almucurbit 1. Weigh 10 kg of dried crude drug of this product, add 55% of 75% ethanol, and heat at reflux for 4 times, each for 2 hours. Filtration, the filtrate recovered ethanol to non-alcoholic taste. The volume of the concentrated aqueous solution was 10 liters, and the pH was adjusted to 2.0-2.5 with 5% hydrochloric acid. The precipitate was collected by filtration. Shaking with ether several times, degreasing.