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为比较补气通络方和神经外膜切开对周围神经急性挤压伤的治疗效果 ,采用清洁级SD大鼠制成精确的右坐骨神经急性挤压伤模型。造模成功后随机分为补气通络胶囊剂组、手术 (神经外膜切开 )组、补气通络胶囊 +手术组和对照组。经过造模给药后 1天、1周、4周、8周作坐骨神经传导速度 (NCV)、阈强度、最大波幅测定作为观测指标 ,判断神经功能的修复情况。结果显示补气通络方及补气通络方 +手术组的坐骨神经传导速度 (NCV)、阈强度、最大波幅均比对照组恢复快 ,有显著性差异 (P <0 .0 5及P <0 .0 1) ;手术 (神经外膜切开 )组虽优于对照组 ,但无统计学意义 (P >0 .0 5 ) ;对照组恢复最慢 ;补气通络方与补气通络方 +手术组之间比较 ,无显著性差异 (P >0 .0 5 )。表明补气通络方对周围神经急性挤压伤后的神经恢复有促进作用 ;单纯神经外膜切开对周围神经急性挤压伤早期可能有帮助 ,但与对照组无显著性差异 ,远期疗效可能因破坏神经营养血管并不确切 ,临床运用价值不大。
In order to compare the therapeutic effects of Buqi Tongluo Fang and neuronervical incision on acute peripheral nerve crush injury, a model of acute crush injury to the right sciatic nerve was made using clean SD rats. After successful modeling, they were randomly divided into Buqi Tongluo capsule group, surgery (neuropexyomy) group, Buqi Tongluo Capsule + surgery group and control group. The sciatic nerve conduction velocity (NCV), threshold intensity, and maximum amplitude measurement were used as observation indicators at one, one, four, and eight weeks after model administration to determine the repair of neurological function. The results showed that the sciatic nerve conduction velocity (NCV), threshold intensity, and maximum amplitude of the Qiqi Tongluo Fang and Buqi Tongluo + surgery group recovered faster than the control group, with significant differences (P <0.05 and P <0.05). 0 .0 1) The surgical (neural epidural incision) group was superior to the control group, but it was not statistically significant (P > 0.05). The control group recovered the slowest; Buqi Tongluo Fang and Buqi Tong. There was no significant difference between the two groups (P > 0.05). It was shown that Buqi Tongluo can promote the nerve recovery after acute crush injury of peripheral nerve; simple epineurium incision may help early acute crush injury of peripheral nerve, but there is no significant difference with the control group. The curative effect may not be definitive due to the destruction of neurotrophic blood vessels, and its clinical application value is not significant.