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为了进一步了解流行性乙型脑炎减毒活疫苗的接种安全性，掌握其免疫效果及免疫持久性，本研究有代表性地抽取2岁以内婴幼儿359名，并将其分为两组，分别接种乙脑灭活疫苗和动脑减毒活疫苗。经现场观察证实，两种疫苗接种后，仅极个别出现轻度接种反应，无严重反应发生，因而两种疫苗均是安全的。采用前瞻性方法研究其免疫学效果发现，基础免疫后，两种疫苗所产生的血清抗体达60％左右，但仅能维持1年，第2年需加强免疫，之后，抗体阳性率迅速提高至90％以上，减毒活疫苗高于灭活疫苗，抗体平均滴度也大为提高。经过2～3年的间隔期减毒活疫苗的抗体阳性率尚维持在80％和70％，而灭疫苗已下降在近50％和35％，提示减毒活疫苗具有更好的免疫学效果、更少的接种次数和接种剂量，适宜于大面积推广应用。根据观察结果，我们认为，乙脑灭活疫苗免疫，应基础免疫2针，间隔7～10天，第2年加强免疫1针之后，间隔1年最迟2年再加强1针。减毒活疫苗基础免疫1针，第2年加强1针，经4～5年后再加强注射。
In order to further understand the vaccination safety of live attenuated JE vaccine and to know the immune effect and immune persistence, 359 infants and young children aged less than 2 years were collected in this study and divided into two groups. Were inoculated with JE inactivated vaccine and live attenuated live brains vaccine. After field observation confirmed that after the two vaccination, only a few mild inoculation reaction, no serious reaction occurs, so both vaccines are safe. The prospective study of its immunological effects found that after the basic immunization, the two vaccines produce about 60% of the serum antibody, but only for 1 year, the second year need to be boosted, then the antibody positive rate increased rapidly to More than 90% live attenuated vaccine inactivated than inactivated vaccine, the average titer is also greatly improved. After 2 to 3 years of interval attenuated live vaccine antibody positive rate remained at 80% and 70%, while the off vaccine has declined in the nearly 50% and 35%, suggesting that attenuated live vaccine has a better immunological effect , Less vaccination and vaccination dose, suitable for large-scale promotion and application. According to the observation, we believe that the JE inactivated vaccine should be immunized on the basis of 2 needles at an interval of 7 to 10 days. After 1 year of intensive immunization in the second year, one needle should be further strengthened at the latest 2 years after the interval of 1 year. Live attenuated vaccine based on a needle, the first 2 years to strengthen a needle, after 4 to 5 years and then strengthen the injection.