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[背景]人们关注产前邻苯二甲酸酯暴露对神经行为的潜在影响,但是现有的数据并不一致。[目的]探讨产前尿中邻苯二甲酸酯代谢物的浓度与儿童神经行为得分之间的相关性。[方法]在一个多中心的队列研究——未来家庭研究(Study for Future Families)中,测定153名妊娠妇女尿液样本中邻苯二甲酸酯代谢物的浓度。当儿童年龄在6~10岁时,由母亲完成儿童行为量表。用调整后的多元回归交互模型,评估邻苯二甲酸酯浓度与儿童行为(总体以及性别特异性)之间的相关性。[结果]男童中,单异丁基邻苯二甲酸浓度与如下项目的较高得分相关:注意力不集中(β=0.27;95%CI:0.04~0.50)、违规行为(β=0.20;95%CI:0.01~0.38)、攻击性(β=0.34,95%CI:0.09~0.59)和品行问题(β=0.39;95%CI:0.20~0.58),而二(2-乙基己基)邻苯二甲酸酯代谢物的摩尔总数与躯体问题的较高得分相关(β=0.15;95%CI:0.03~0.28)。较高的单苄基邻苯二甲酸浓度与男童中对抗行为(β=0.16;95%CI:0.01~0.32)和品行问题(β=0.21;95%CI:0.06~0.37)的较高得分相关,但与女童中较低的焦虑得分(β=-0.20;95%CI:-0.39~-0.01)相关。通常,在女童中上述相关性接近于零。模型系数表明,平方根转化后的结果得分的差异与对数变换的代谢产物每增加1个单位相关。[结论]上述研究结果提示,妊娠后期某些邻苯二甲酸盐暴露与男童的行为问题之间存在相关性。鉴于有关这一课题的研究很少,以及在研究中存在方法学和人群的差异,因此需要进行更多的研究。
[Background] People are concerned about the potential impact of prenatal phthalate exposure on neurological behavior, but the available data are not consistent. [Objective] To investigate the correlation between prenatal urinary phthalate metabolites concentration and children’s neurobehavioral scores. [Method] In a multicenter cohort study, Study for Future Families, the concentrations of phthalate metabolites in urine samples from 153 pregnant women were determined. When the child is between 6 and 10 years of age, the child’s behavior scale is completed by the mother. Adjusted multivariate regression interaction models were used to assess the correlation between phthalate concentrations and child behavior (overall and gender-specific). [Results] The concentration of monoisobutylphthalic acid in boys was associated with higher scores for items of inadequate attention (β = 0.27; 95% CI: 0.04-0.50), irregularities (β = 0.20; 95% CI: 0.01-0.38), aggressiveness (β = 0.34, 95% CI: 0.09-0.59) and conduct problems (β = 0.39; 95% CI: 0.20-0.58) The total molar amount of dicarboxylic acid ester metabolites correlated with the higher body-matter score (β = 0.15; 95% CI: 0.03-0.28). The higher monobenzyl phthalate concentrations were associated with higher scores in adolescent boys (β = 0.16; 95% CI: 0.01-0.32) and conduct problems (β = 0.21; 95% CI: 0.06-0.37) But was associated with lower anxiety scores among girls (β = -0.20; 95% CI: -0.39 ~ -0.01). Often, the above correlation in girls is close to zero. The model coefficients show that the difference in the square root transformed result scores correlates with every 1 unit increase in the log transformed metabolites. [Conclusion] The above results suggest that there is a correlation between some phthalates exposure during pregnancy and the behavior problems of boys. Given the paucity of studies on this topic and the differences in methodologies and populations in the study, more research is needed.