论文部分内容阅读
目的对某丙烯酰胺生产车间工人血清生化指标进行分析,探讨目前生产过程中丙烯酰胺对职业人群生化指标的影响。方法检测生产车间丙烯酰胺浓度,选取该厂32名接触丙烯酰胺的工龄超过10年的工人为接触组,以工龄超过10年的不接触丙烯酰胺的32名工人为非接触组,进行职业流行病学调查,并对其生化指标进行检测,对相关资料进行t检验和χ2检验。结果生产车间5个生产点丙烯酰胺检测结果(cTWA)为0.15~0.28 mg/m3,符合国家职业卫生标准。各项生化指标中,谷丙转氨酶(ALT)、谷草转氨酶(AST)、直接胆红素(DBIL)、甘油三酯(TG)的测量均值与非接触组比较,差异均有统计学意义(t=1.703、1.937、10.173、0.664,P<0.05)。三大类生化指标中,接触组的肝功能和血脂指标异常率高于非接触组,差异有统计学意义(χ2=33.890、5.497,P<0.05)。结论低浓度长期接触丙烯酰胺对人体血清生化指标有明显影响,可能导致车间工人的肝脏受损和血脂异常。应加强接触人群的保护措施,减少职业接触,防止职业病的发生。
Objective To analyze the serum biochemical indexes of acrylamide workshop workers and discuss the influence of acrylamide on the biochemical indexes of occupational groups in the current production process. Methods The concentration of acrylamide in the workshop was measured. 32 workers in the factory who had been exposed to acrylamide for more than 10 years were selected as the exposure group and 32 workers without exposure to acrylamide for more than 10 years were employed as the non-contact group for occupational epidemics Study, and its biochemical indicators were tested, the relevant data t test and χ2 test. Results Acrylamide test results (cTWA) were 0.15-0.28 mg / m3 at 5 production sites in the workshop, which met the national occupational health standards. The biochemical indicators, ALT, AST, DBIL, triglyceride (TG) measured mean compared with the non-contact group, the difference was statistically significant (t = 1.703, 1.937, 10.173, 0.664, P <0.05). The three categories of biochemical indicators, the contact group of liver function and blood lipid abnormalities were higher than the non-contact group, the difference was statistically significant (χ2 = 33.890,5.497, P <0.05). Conclusion Low concentration of long-term exposure to acrylamide has significant effect on human serum biochemical indicators, which may lead to liver damage and dyslipidemia in workshop workers. We should step up protection measures for reaching people, reduce occupational exposure and prevent occupational diseases from occurring.