论文部分内容阅读
任何一种肾小球疾病进行性发展的最终结局是肾小球硬化。如何尽早地对患者肾小球硬化的发生做出预测,进而采取相应的措施来阻止肾小球硬化的发生是当今肾脏病研究领域一个非常引人瞩目的课题,尤其是有关临床应用方面的研究则更具其实用推广价值。目前,借助肾小球疾病患者肾活检标本进行分子病理学检测和对患者分子遗传学基础一致病基因多态性进行分析是这方面研究的两个最新动态。 一、肾活检标本分子病理学检测 细胞外基质(ECM)增生是肾小球硬化早期形态学改变之一。构成ECM的主要成份包括Ⅳ型胶
The final outcome of any progressive progression of glomerular disease is glomerulosclerosis. How to predict the occurrence of glomerulosclerosis in patients as early as possible and then take appropriate measures to prevent the occurrence of glomerulosclerosis is a very attractive topic in the field of kidney disease research, especially the research on clinical application It is more practical and promotional value. At present, the molecular pathology of renal biopsy specimens of patients with glomerular diseases and analysis of the genetic basis of the disease-related genes in patients with polymorphism are the two latest developments in this area. First, the renal biopsy specimens molecular pathology detection Extracellular matrix (ECM) proliferation is one of the early morphological changes of glomerulosclerosis. The main ingredients that make up ECM include type IV glue