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研究了避蚊酯原药的急性和亚慢性毒性及致突变性。结果显示:大鼠经口LD50雌性为10000mg/kg,雄性为12100mg/kg,大鼠经皮LD50雌雄性均大于2000mg/kg。家兔急性皮肤刺激试验,对皮肤的刺激强度属无刺激性。家兔眼刺激试验,对眼的刺激强度属中度刺激性。小鼠骨髓多染红细胞微核试验和小鼠睾丸精母细胞染色体畸变试验均为阴性。大鼠亚慢性经口毒性试验,对体重、摄食量、食物利用率、血液指标及血液生化指标均无明显影响,11000mg/kg饲料组雌性大鼠肾/体比、雄性大鼠肝/体比可见增高。病理检查发现,11000mg/kg饲料组4只大鼠可见肝脏1￣2个小炎症灶,2只大鼠少数肾小管上皮细胞肿胀。最大无作用剂量为:雌性大鼠393.67±26.98mg/kg·d,雄性大鼠336.65±26.38mg/kg·d。
Acute and subchronic toxicity and mutagenicity of the mosquito repellent drug were studied. The results showed that the oral LD50 of female was 10000mg / kg in female and 12100mg / kg in male. The LD50 of male and female percutaneous LD50 in rats were both higher than 2000mg / kg. Rabbit acute skin irritation test, the skin irritation intensity is non-irritating. Rabbit eye irritation test, the eye irritation intensity is moderate irritation. Mice bone marrow polychromatic erythrocyte micronucleus test and mouse testicular spermatocyte chromosome aberration test were negative. Subchronic oral toxicity test in rats had no significant effect on body weight, food intake, food utilization rate, blood index and blood biochemical indexes. The ratio of kidney / body in 11000mg / kg diet group to that in male rat liver / body ratio Visible higher. Pathological examination found that 11000mg / kg feed group 4 rats visible liver 1 to 2 small inflammatory lesions, 2 rats a few renal tubular epithelial cells swelling. The maximum no effect dose: female rats 393.67 ± 26.98mg / kg · d, male rats 336.65 ± 26.38mg / kg · d.