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目的大动脉炎(Takayasu arteritis)是累及主动脉及其主要分支的慢性进行性血管炎性疾病,肿瘤坏死因子α(Tumor necrosis factorα,TNF-α)是体内重要的细胞因子,本研究通过分析其在血浆中的水平探讨其与大动脉炎的相关性。方法采用病例对照研究方法,入选大动脉炎患者45例,对照组为与病例组年龄、性别相匹配的60例健康者。应用酶联免疫吸附法(Enzyme linked immunosorbent assay,ELISA)测定患者及正常对照组血浆中TNF-α水平。结果活动期大动脉炎患者血浆TNF-α水平较正常对照组及非活动期大动脉炎患者显著升高。中重型、难治性大动脉炎患者血浆TNF-α也明显升高。结论血浆TNF-α水平可作为判断大动脉炎活动性、监测病情的血清学标志。
Objective Takayasu arteritis is a chronic progressive inflammatory disease involving the aorta and its major branches. Tumor necrosis factor α (TNF-α) is an important cytokine in the body. In this study, Plasma level to explore its association with arteritis. Methods A case-control study was conducted in 45 patients with aortitis and 60 healthy controls matched with the age and sex of the patients in the control group. The level of TNF-α in plasma and plasma of patients and normal control group were measured by enzyme-linked immunosorbent assay (ELISA). Results The plasma level of TNF-α in active arteritis patients was significantly higher than that in normal controls and in patients with aorta arteritis. In severe, refractory aortitis in patients with plasma TNF-α was also significantly higher. Conclusions Plasma TNF-α level can be used as a serological marker to judge the activity of arteritis and monitor the condition.