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目的探讨3种黄体支持方法对不孕患者体外受精-胚胎移植(in vitro fertility and embryo transfer,IVF-ET)术后妊娠结局的影响。方法对240例进行IVF-ET的不孕患者进行回顾性分析,按取卵后不同的黄体支持方法分为3组,每组80例。A组采用口服黄体酮胶囊进行黄体支持;B组采用地屈孕酮片进行黄体支持;C组采用肌肉注射黄体酮针剂进行黄体支持。结果 A、B、C组3组所获得的临床妊娠率、异位妊娠率、多胎妊娠率及早期流产率均无显著性差异(P>0.05)。结论对不孕患者在IVF-ET术后口服黄体酮胶囊或口服地屈孕酮进行黄体支持与肌肉注射黄体酮针剂进行黄体支持所获得的妊娠结局是一致的,在临床上可以考虑将口服孕酮替代黄体酮针剂进行黄体支持。
Objective To investigate the effect of three methods of luteal support on postoperative pregnancy outcome in in vitro fertility and embryo transfer (IVF-ET). Methods A retrospective analysis was performed on 240 infertile patients who underwent IVF-ET. According to the different methods of luteal support after ovulation, they were divided into 3 groups of 80 cases each. In group A, progesterone capsules were used for luteal support; in group B, progesterone tablets were used for luteal support; in group C, progesterone was used for luteal support. Results There was no significant difference in clinical pregnancy rate, ectopic pregnancy rate, multiple pregnancy rate and early miscarriage rate among groups A, B and C (P> 0.05). CONCLUSIONS: Pregnancy outcomes obtained in patients with infertility undergoing luteal support with oral progesterone orally with progesterone capsules or with progesterone administered orally by IVF-ET are consistent with those obtained with corpus luteum support. Intravenous pregnancies may be considered clinically Progesterone in place of progesterone for lutein support.