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目的:研究中药复方“生发灵215”的两种提取方法和生发作用。方法:参考该中药复方的传统临床应用,考察了该复方的两种提取方法:一是用油提取直接涂抹的传统方法,一是用醇提法并制成软膏剂。然后用两种提取物对试验兔进行皮肤刺激性实验和促毛发生长作用的初步探讨。结果:软膏剂在外观、手感以及使用舒适度方面均大大优于传统的油提取物。皮肤刺激实验表明油提物对完整皮肤和破损皮肤均有刺激性,而通过醇提物制备的软膏制剂作用温和,没有发现明显的刺激性。毛发生长实验表明,醇提物制备的软膏制剂在促毛发生长效果方面和油提物没有明显差异。结论:醇提物制成的软膏剂具有良好的临床应用价值。
Objective: To study the two extraction methods and germinal effects of Chinese herbal compound “Sheng-Fa-Ling 215”. Methods: With reference to the traditional clinical application of the traditional Chinese medicine compound, two extraction methods of the compound were investigated: one is the traditional method of direct painting with oil, the other is the method of alcohol preparation and the preparation of ointment. Then, two kinds of extracts were used to test skin irritation and hair growth in rabbits. Results: Ointments outperform traditional oil extracts in terms of appearance, feel and comfort of use. Skin irritation experiments showed that oil extracts irritated both intact and damaged skin, while ointment preparations prepared from alcohol extracts were mild and found no significant irritation. Hair growth experiments showed that alcohol extract prepared ointment preparations and oil-promoting effect is no significant difference between the oil extract. Conclusion: The alcohol extract made ointment has good clinical value.