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目的分析丙氨酰谷氨酰胺不合理使用引发的不良反应情况,提高临床用药合理性。方法选取重庆市职业病防治院2014年2月收治的静脉滴注丙氨酰谷氨酰胺患者1245例,分析药物不良反应发生情况,并根据患者用药指征、剂量、时间及药物配比分析不合理使用情况。结果 1245例患者中出现不良反应124例(9.96%)。124例患者中不完全符合用药指征占18.55%,与5%葡萄糖溶液500 ml、0.9%氯化钠溶液500 ml配伍不合理占33.90%,与复方氨基酸500 ml配伍不合理占47.60%,与>1000 ml含脂肪乳、氨基酸、电解质、微量元素的溶液配伍不合理占18.50%。使用时间不合理主要集中在2~10 d。结论药物配比浓度及成分、超范围使用、禁忌证使用是丙氨酰谷氨酰胺不合理使用引发的不良反应的主要原因。
Objective To analyze the adverse reactions caused by the improper use of alanylglutamine and to improve the rationality of clinical medication. Methods 1245 cases of alanine glutamine intravenously dripped by Chongqing Occupational Disease Prevention and Control Hospital in February 2014 were selected to analyze the incidence of adverse drug reactions. According to the indications, dosage, time and drug match of patients Usage. Results A total of 124 adverse reactions (9.96%) occurred in 1245 patients. 124 patients did not fully meet the indications for medication accounted for 18.55%, 500 ml with 5% glucose solution, 500 ml of 0.9% sodium chloride solution unreasonable 33.90% compatibility, unreasonable with the compound amino acid 500 ml accounting for 47.60%, and > 1000 ml fat emulsion, amino acids, electrolytes, trace elements unreasonable solution compatibility 18.50%. Irrational use of time mainly concentrated in 2 ~ 10 d. Conclusion The drug concentration and composition, over-range use, the use of contraindications is the main reason for adverse reactions caused by the improper use of alanyl-glutamine.