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目的观察丁咯地尔联合甲钴胺治疗糖尿病周围神经病变(DPN)的疗效。方法 62例DPN患者随机分为治疗组和对照组各31例,治疗组给予丁咯地尔联合甲钴胺治疗,对照组仅给予甲钴胺治疗。测定两组患者治疗前后正中神经和腓总神经的运动神经传导速度(MCV)和感觉神经传导速度(SCV)。结果治疗后治疗组和对照组的MCV和SCV分值均比治疗前改善(P<0.05),治疗组比对照组改善更明显。结论丁咯地尔联合甲钴胺治疗DPN优于单纯甲钴胺治疗。
Objective To observe the efficacy of buflomedil combined with mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods 62 patients with DPN were randomly divided into treatment group and control group of 31 cases, the treatment group was given buflomedil combined with mecobalamin treatment, the control group was given mecobalamin only. Motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV) of the median nerve and common peroneal nerve were measured before and after treatment in both groups. Results After treatment, MCV and SCV scores of treatment group and control group were improved than before treatment (P <0.05), and the improvement of treatment group was more obvious than that of control group. Conclusions Buflomedil and mecobalamin are superior to mecobalamin in the treatment of DPN.