The role of autophagic and lysosomal pathways in ischemic brain injury

• 作 者: Zhaohua Gu Yinyi Sun Kangyong
• 机 构: DepartmentofNeurology,DepartmentofNeurology,DepartmentofNeurobiology,DepartmentofNeurology
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2013年23期
• 关键词: 缺血性脑损伤 溶酶体 自噬 神经细胞死亡 组织蛋白酶B WESTERN印迹 透射电子显微镜 共聚焦显微镜 neural regeneration brain i
• 基金项目: supported by grants from the National Natural Science Foundation of China,No.31171014 and No.30970869,the Project of Science and Technology Commission of ShanghaiCity,No.09DZ1950400,Board of Health of

Autophagy is involved in neural cell death after cerebral ischemia. Our previous studies showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was in-creased after the autophagy inhibitor, 3-methyladenine, was