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探讨滋肾宁心方对去势雌兔喂饲高脂饲料后性激素的影响及血脂的变化,阐明该方对绝经后心血管病的保护作用。方法:36只日本大耳白兔随机分为假手术组(A)、去势+高脂饲料组(B)、去势+高脂饲料组+滋肾宁心方组(C)、去势+高脂饲料组+倍美力组(D),每组9只,去势组切除卵巢,假手术组只切开不摘除卵巢,手术后,A、B组给等量的冷开水,C、D组分别饲以相应药物,12周后抽血检测,采用酶法检测血脂水平,放射免疫法检测血清性激素水平。结果:两药对E2水平的影响无差异,FSH、LH水平去势后均有增高,但中药组与假手术组无统计学意义;两药均能降低TC和LDL-C水平,对TG无影响,对HDL-C和APOA1水平有降低的作用。结论:滋肾宁心方对去势后雌兔E2水平无影响,但有降低FSH、LH的作用;对高脂所致的TC和LDL-C升高有降低作用,可能是其治疗绝经后冠心病的作用机制之一。
To investigate the effect of Zishen Ningxin recipe on sex hormones and blood lipids of castrated female rabbits fed with high-fat diet, and to clarify the protective effect of this prescription on postmenopausal cardiovascular disease. METHODS: Thirty-six Japanese white rabbits were randomly divided into sham operation group (A), castration + high fat diet group (B), castrate + high fat diet group + Zishenningxinfang group (C), castration. + High-fat diet group + Premarin group (D), 9 in each group. The ovariectomized group was ovariectomized. The sham-operated group was only incised and the ovary was not removed. After the surgery, group A and B were given the same amount of cold boiled water. The group D and group D were fed with the corresponding drugs respectively. Blood samples were taken after 12 weeks. Serum lipid levels were detected by enzymatic methods and serum sex hormone levels were measured by radioimmunoassay. Results: There was no difference in the effect of the two drugs on E2 levels. After FSH and LH levels were increased after castration, there was no statistical significance between the Chinese medicine group and the sham operation group. Both drugs were able to reduce the levels of TC and LDL-C. Effects, have a reduced effect on HDL-C and APOA1 levels. Conclusion: Zishen Ningxin recipe has no effect on E2 level in ovariectomized female rabbits, but it has the effect of lowering FSH and LH; it may reduce the increase of TC and LDL-C caused by high fat, and may be its treatment of postmenopausal women One of the mechanisms of coronary heart disease.