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本文对经临床确诊的高血压病、Ⅱ型糖尿病、冠心病、高脂血症、肝癌、门脉性肝硬化等患者共计４２７例的血清总胆固醇（ＴＣ），甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）及亚类（ＨＤＬ２－乙ＨＤＬ３－３）、低和极低密度脂蛋白胆固醇（ＬＤＬ－Ｃ和ＶＬＤＬ－Ｃ）以及比值作了分析研究。结果表明，上述前３种疾病中ＴＣ、ＴＧ、ＨＤＬ－Ｃ任一指标异常者分别为６８．２％、５６．２％、６４．６％，经逐步回归优选出的ＨＤＬ２－Ｃ、ＨＤＬ３－Ｃ及与其有关的比值指标则有８４．７％、８７．５％、８５．８％的患者表现出有脂质代谢的紊乱。因此ＨＤＬ－Ｃ及亚类与ＴＣ、ＴＧ等的比值对了解脂代谢紊乱是敏感的指标。此外ＨＤＬ３－Ｃ在肝癌和肝硬化患者血清中其浓度与胆碱脂酶、蛋白比值呈显著正相关，可为判断肝功能状况的指标。
In this paper, 427 patients with clinically diagnosed hypertension, type II diabetes, coronary heart disease, hyperlipidemia, liver cancer, portal cirrhosis and other patients total serum cholesterol (TC), triglyceride (TG) HDL-C and subclass (HDL2-B HDL3-3), LDL-C and VLDL-C and their ratios were analyzed. The results showed that the abnormalities of TC, TG and HDL-C were 68.2%, 56.2% and 64.6% respectively in the above three kinds of diseases. The HDL2-C and HDL3- C and related indicators of the ratio of 84.7%, 87.5%, 85.8% of patients showed lipid metabolism disorder. Therefore, the ratio of HDL-C and subclasses to TC, TG, etc. is a sensitive indicator for understanding lipid metabolism disorders. In addition, the concentration of HDL3-C in serum of patients with liver cancer and cirrhosis is positively correlated with the ratio of cholinesterase and protein, which may be an index to judge the status of liver function.