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目的探讨血清抵抗素(resistin)、氧化型低密度脂蛋白(ox-LDL)及超敏C反应蛋白(hs-CRP)在脑血管病发病机制中的作用及临床意义。方法缺血性脑血管患者91例为观察组,28例可逆性缺血性脑损伤患者(RIBD组)、36例短暂性脑缺血发作患者(TIA组)、27例局限性脑梗塞患者(FCI组),选同期健康志愿者71例为对照组。对比各组血清resistin、ox-LDL、hsCRP水平,并分析其与脑血管病严重程度相关性。结果 FCI、RIBD、TIA组血清resistin、ox-LDL、hs-CRP水平明显高于对照组(P<0.05);RIBD、FCI组resistin、ox-LDL、hs-CRP水平明显高于TIA组(P<0.05);Spearman相关分析显示血清resistin、ox-LDL、hs-CRP水平与脑血管严重程度呈正相关性(r_1=0.902,P_1=0.010;r_2=0.765,P_2=0.010;r_3=0.829,P_3=0.000)。结论血清resistin、ox-LDL、hs-CRP水平与脑血管病严重程度相关,并参与脑血管病的发生与发展。
Objective To investigate the role and clinical significance of serum resistin, ox-LDL and hs-CRP in the pathogenesis of cerebrovascular disease. Methods Totally 91 ischemic cerebrovascular patients were included in the observation group, 28 patients with reversible ischemic brain injury (RIBD), 36 patients with transient ischemic attack (TIA), 27 patients with cerebral infarction FCI group), 71 healthy volunteers were selected as the control group. The levels of resistin, ox-LDL and hsCRP in each group were compared, and their correlations with the severity of cerebrovascular disease were analyzed. Results The levels of resistin, ox-LDL and hs-CRP in FCI, RIBD and TIA groups were significantly higher than those in control group (P <0.05). The levels of resistin, ox-LDL and hs-CRP in RIBD and FCI group were significantly higher than those in TIA group (P <0.05). Spearman correlation analysis showed that the levels of resistin, ox-LDL and hs-CRP were positively correlated with the severity of cerebrovascular disease (r_1 = 0.902, P_1 = 0.010; r_2 = 0.765, 0.000). Conclusion The serum levels of resistin, ox-LDL and hs-CRP are correlated with the severity of cerebrovascular disease and are involved in the occurrence and development of cerebrovascular disease.