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一般认为支气管粘膜上皮非典型增生是肺癌的癌前病变。此研究通过应用叶酸和维生素B12治疗吸烟者的支气管粘膜上皮非典型增生达到化学预防肺癌的目的。研究对象为经纤支镜活检诊断的30例支气管粘膜上皮非典型增生病人。治疗组17例（27个病灶），对照组13例（18个病灶）。治疗组每日口服叶酸10mg和维生素B12750μg，3个月。组织学异型程度用0～4的等级判定。结果表明，治疗组在治疗前组织异型程度平均为1．6，治疗后为0．3，两者比较有显著性差异（P＜0．01）．对照组前后变化不明显，分别为1．3和1．1。测定血中叶酸和维生素B12浓度，在治疗组维持较高的浓度。作者认为叶酸和维生素B12有治疗肺癌癌前病变支气管粘膜非典型增生的作用。
It is generally believed that bronchial epithelial dysplasia is a precancerous lesion of lung cancer. This study aims to chemoprevent lung cancer by using folic acid and vitamin B12 to treat atypical hyperplasia of bronchial epithelium in smokers. The subjects were 30 cases of bronchial epithelial dysplasia diagnosed by bronchoscopic biopsy. The treatment group consisted of 17 patients (27 lesions) and the control group 13 patients (18 lesions). The treatment group received oral administration of folic acid 10 mg and vitamin B 12750 μg daily for 3 months. The degree of histological abnormality was judged on a 0 to 4 scale. The results showed that the treatment group had an anomaly of 1.6 before treatment and 0.3 after treatment. There was a significant difference between the two groups (P<0.01). There was no significant change before and after the control group, which was 1.3 and 1.1 respectively. Blood levels of folic acid and vitamin B12 were measured and maintained at higher concentrations in the treatment group. The authors believe that folic acid and vitamin B12 have a role in the treatment of lung cancer precancerous bronchial mucosa atypical hyperplasia.