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近年来,国内外医药科研工作者为攻克肿瘤,进行了许多肿瘤方面的基础研究。最引人注意的是细胞膜基础研究,为寻找非细胞毒类的低毒高效药物提供了有力的依据;特别是普克、帕斯特恩二个研究小组分别报告了以二丁酰环腺苷酸处理,能引起组织培养中的肿瘤细胞失去肿瘤转化的特征,使其形态接近于正常细胞。二丁酰环腺苷酸诱导的这一过程被称为“逆向转化”,逆向转化伴随着微管-微丝这种作为细胞骨架的有收缩性的细胞器的重新组织。因此普克又提出,细胞的分化与一种依赖于环腺苷酸的微管-微丝网络有关,微管-微丝的一端连结细胞膜的成份,另一端则连结于核结构,在发生恶性转化的细胞中,这种网络被瓦解了,而环腺苷酸能
In recent years, domestic and foreign medical research workers to overcome the tumor, conducted many basic research in cancer. The most notable is the basic research of the cell membrane, which provides a strong basis for searching for non-cytotoxic drugs with low toxicity and high efficiency. In particular, two research teams of Pock and Pastran have respectively reported the treatment with dibutyryl cyclic adenosine monophosphate , Can cause the tumor cells in tissue culture to lose the characteristics of tumor transformation, making its morphology close to that of normal cells. This process, induced by dibutyrylcyanidic acid, is termed “retrotransformation,” which is accompanied by the reorganization of contractile organelles, such as microtubules, which act as cytoskeletons. Therefore, Puke also proposed that the differentiation of the cells is related to a microtubule-microfilament network that depends on cyclic adenosine monophosphate. One end of the microtubule-microfilament connects the components of the cell membrane and the other end is connected to the nuclear structure. In transformed cells, this network is disrupted, whereas cyclic adenosine acid can