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结核分枝杆菌主要是通过呼吸道传播,而机体的呼吸道黏膜免疫又是抵御从黏膜途径入侵的外来物质的第一道防线。因此,诱导有效的黏膜免疫应答对结核分枝杆菌感染的预防和治疗性疫苗的研制具有重要的价值。
Mycobacterium tuberculosis is mainly spread through the respiratory tract, and the body’s respiratory mucosal immunity is the first line of defense against foreign substances from the mucosal invasion. Therefore, induction of an effective mucosal immune response is of great value to the prevention of Mycobacterium tuberculosis infection and the development of therapeutic vaccines.