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枯否(Kupffer)细胞是巨噬细胞中最重要的细胞之一,分布于肝窦状隙内。它们主要清除来自肠道血中的微生物和内毒素,也能清除抗原、抗原-抗体复合物、乳糜微粒和衰老的红细胞。最近有人认为,内皮细胞可能转为枯否细胞,其根据是:在反复注射胶状物质后,枯否细胞数增加,但在电镜下,内皮细胞和枯否细胞的结构不同,由前者转为后者似不可能。有人指出,枯否细胞是一种自养细胞;换言之,在正常情况下,枯否细胞通过分裂而发生复制,然而在正常动物试验中,很少能观察到枯否细胞的有丝分
Kupffer cells are one of the most important macrophages in the hepatic sinusoids. They mainly remove microorganisms and endotoxins from intestinal blood, and also remove antigens, antigen-antibody complexes, chylomicrons and aging red blood cells. Recently, some people think that endothelial cells may be converted to Kupffer cells, based on the following: after repeated injection of colloidal substances, Kupffer cells increased, but under the electron microscope, the structure of endothelial cells and Kupffer cells from the former to The latter seems impossible. It has been pointed out that Kupffer cells are an autotrophic cell; in other words, under normal conditions, Kupffer cells replicate by division, however, in normal animal experiments, there is very little evidence of kinetochore mitochondria