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目的探讨DKK1与β-Catenin在食管鳞癌中的表达及与临床病理特征的关系。方法采用免疫组化二步法检测DKK1,β-Catenin在54例食管鳞癌中的表达情况,。结果 DKK1在食管鳞癌高中和低分化组中阳性率分别为82.14%和38.46%,在TNMⅠ、Ⅱ期和Ⅲ、Ⅳ期组中阳性率分别为43.47%和74.19%,肿瘤浸润深度分组(浅肌层,深肌层,外膜)中,DKK1阳性率分别为50.00%,42.86%,74.19%,在淋巴结转移组与非转移中DKK1阳性率分别为76.00%和48.28%,统计学显示,以上四个变量均有显著差异(P<0.05)。β-catenin在食管鳞癌高中和低分化组中阳性率分别为46.42%和88.46%,淋巴结转移组与非转移中阳性率分别为44.00%和86.21%,统计学显示两变量具有显著差异(P<0.05)。结论 DKK1,β-catenin在食管鱗癌分化、增殖,转移中起一定的作用,DKK1作为Wnt/β-Catenin经典信号传导通路的拮抗剂,有可能成为新的药物作用靶点。
Objective To investigate the expression of DKK1 and β-Catenin in esophageal squamous cell carcinoma and its relationship with clinicopathological features. Methods Immunohistochemical two-step method was used to detect the expression of DKK1 and β-Catenin in 54 cases of esophageal squamous cell carcinoma. Results The positive rates of DKK1 in esophageal squamous cell carcinoma were 82.14% and 38.46%, respectively. The positive rates of DKK1 in TNMⅠ, Ⅱ and Ⅲ, Ⅳ were 43.47% and 74.19%, respectively The positive rates of DKK1 were 50.00%, 42.86% and 74.19% in the muscular layer, deep muscular layer and adventitia, respectively. The positive rates of DKK1 in lymph node metastasis group and non-metastatic group were 76.00% and 48.28% respectively. According to statistics, All four variables were significantly different (P <0.05). The positive rates of β-catenin in esophageal squamous cell carcinoma were 46.42% and 88.46%, respectively. The positive rates of β-catenin in esophageal squamous cell carcinoma were 44.00% and 86.21%, respectively. Statistical analysis showed that there was significant difference between the two variables <0.05). Conclusions DKK1 and β-catenin play roles in the differentiation, proliferation and metastasis of esophageal squamous cell carcinoma. DKK1, as an antagonist of Wnt / β-Catenin signaling pathway, may be a new drug target.