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目的:探讨非霍杰金淋巴瘤(NHL)骨髓侵犯发生率与临床分期和病理分型的关系。方法:160例NHL患者均做骨髓涂片和骨髓活检,48例骨髓侵犯病例做免疫组织化学染色。结果:骨髓涂片和活检侵犯率分别为18.7%和30.0%,骨髓涂片噬血现象多见Ⅳ期。骨髓侵犯的NHL病理组织分型以B细胞为主,骨髓侵犯模式以弥散型为主。结论:骨髓活检可提高淋巴瘤骨髓侵犯的诊断率,噬血现象出现和临床分期有关。
Objective: To investigate the relationship between non-Hodgkin’s lymphoma (NHL) bone marrow invasion and clinical stage and pathological classification. Methods: A total of 160 NHL patients underwent bone marrow smear and bone marrow biopsy, and 48 cases of bone marrow invasion were examined by immunohistochemical staining. Results: The rates of bone marrow smear and biopsy were 18.7% and 30.0% respectively. The hemophagocytosis of bone marrow was more common in stage Ⅳ. Bone marrow invasion of NHL pathological tissue type B-cell-based, bone marrow invasion model to diffuse-based. Conclusion: Bone marrow biopsy can improve the diagnosis rate of bone marrow invasion of lymphoma. The phenomenon of hemophagocytosis is related to clinical stage.