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目的 动态观察肝炎肝硬化患者红细胞I型补体受体基因点突变与数量表达及其天然免疫黏附功能 (erythrocytecellnature immune adhesionfunction ,RNIAF)的变化 ,探讨它们在评估肝炎肝硬化病情严重程度中的应用价值。方法 分别检测 13 4例肝炎肝硬化不同分级的I型补体受体基因点突变与数量表达及其RNIAF的变化。结果 与正常人群相比较 ,肝硬化患者I型补体受体基因点突变率无统计学差异 ,而肝硬化Child分级各组的CRl数量表达及RNIAF都明显低于正常人群组 ,且随着分级病情严重 ,CRl、RNIAF逐渐降低。结论 红细胞I型补体受体活性及天然免疫黏附功能可灵敏地反映肝炎肝硬化患者病情的发展 ,红细胞CRl及RNIAF可作为判断肝炎肝硬化病情严重程度的重要参考指标
Objective To observe the changes of erythrocyte type I complement receptor gene point mutation and its innate immune adhesion function (RNIAF) in patients with liver cirrhosis and to explore their value in assessing the severity of hepatitis cirrhosis. Methods The level of point mutation, quantitative expression and RNIAF of 134 cases of different grades of hepatitis C cirrhosis were detected respectively. Results Compared with the normal population, there was no significant difference in the point mutation rate of type I complement receptor gene in patients with cirrhosis, while the expression of CR1 and RNIAF in the cirrhotic patients with Child classification were significantly lower than those in the normal population Serious illness, CRl, RNIAF gradually decreased. CONCLUSION: The activity of erythrocyte type I complement receptor and natural immune adhesion function can sensitively reflect the development of the disease in patients with cirrhosis of liver. The erythrocyte CR1 and RNIAF may be used as important reference indexes for judging the severity of hepatitis cirrhosis