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目的:探讨复方甘草酸苷治疗慢性乙型肝炎肝纤维化的临床疗效。方法:150例患者随机分为2组各75例,对照组进行常规保肝治疗,治疗组加用复方甘草酸苷,4周为一疗程。测定治疗前后的肝功能及肝纤维化指标。结果:治疗组和对照组总有效率分别为93.3%和84.0%,组间比较差异有显著性(P<0.05);治疗后2组患者肝功能及肝纤维化指标均有一定程度改善,其中治疗组肝功能ALT、AST、GGT、TBIL及肝纤维化指标HA、LN、PCⅢ、IVC、TGF-β1的改善程度均优于对照组(P<0.05或P<0.01)。结论:复方甘草酸苷可明显改善慢性乙型肝炎患者肝功能、减轻肝纤维化,值得临床推广应用。
Objective: To investigate the clinical efficacy of compound glycyrrhizin in the treatment of chronic hepatitis B liver fibrosis. Methods: One hundred and fifty patients were randomly divided into two groups of 75 cases. The control group received conventional hepatoprotective therapy. The treatment group was given compound glycyrrhizin for 4 weeks. Determination of liver function before and after treatment and liver fibrosis indicators. Results: The total effective rates of the treatment group and the control group were 93.3% and 84.0%, respectively, with significant difference between the two groups (P <0.05). After treatment, the liver function and liver fibrosis indexes of both groups improved to some extent, of which, The improvement of ALT, AST, GGT, TBIL and HA, LN, PCⅢ, IVC and TGF-β1 of liver function in treatment group were better than those in control group (P <0.05 or P <0.01). Conclusion: Compound glycyrrhizin can significantly improve liver function and reduce liver fibrosis in patients with chronic hepatitis B, which is worthy of clinical application.