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以ABC—ELISA法检测了220例成年人重症肌无力病者血清中IgG-Ach-Rab和IgG PrMab。根据检测抗体的阳性发现和临床特点,将重症肌无力分为四组:(Ⅰ)IgG-AchRab阳性,(Ⅱ)IgG-PrMab阳性,(Ⅲ)IgG-AchRab和IsG-PrMab均阳性,(Ⅳ)IgG-AchRab和IgG-PrMab均在正常范围。分析各组临床特点和对激素治疗反应认为:(1)型病者病程较长,激素治疗即时效果好,但易复发;(2)型病程短,激素治疗效果好,而且无复发;(3)型病程也短,激素治疗和胸腺切除效果较差,合并其它自身免疫病的机会高;(4)型激素治疗反应差,胸腺切除治疗效果好。
The serum IgG-Ach-Rab and IgG PrMab in 220 adult patients with myasthenia gravis were detected by ABC-ELISA. According to the positive findings and clinical features of the tested antibodies, myasthenia gravis were divided into four groups: (Ⅰ) IgG-AchRab positive, (Ⅱ) IgG-PrMab positive, (Ⅲ) IgG-AchRab and IsG- ) Both IgG-AchRab and IgG-PrMab are in the normal range. Analysis of the clinical characteristics of each group and the response to hormone therapy that: (1) longer duration of type disease, immediate effect of hormone therapy is good, but easy to relapse; (2) short duration of disease, hormone therapy is good, and no recurrence; ) Type of course is also short, hormone therapy and thymectomy less effective, combined with other autoimmune diseases have a high chance of; (4) type hormone response is poor, thymectomy treatment effect is good.