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一、普罗帕酮静脉注射的即时效果。12～58岁的12(男7、女5)例典型的WPW综合征(10例)和隐匿性附加通道(2例)患者参加了随机、双盲、安慰剂对照的条件交叉试验,各例均有晕厥史和/或室上性心律失常反复发作史且经常规抗心律失常药物治疗无效。试验前至少停用心脏活性药物5个半衰期,仅1例继续服用胺碘达隆(200mg/d)者例外。插管开始电生理测试,首先诱发持续性室上(性心动过)速,然后(在10分钟内)静脉注入普罗帕酮2mg/kg(或安慰剂),若无效改用程序电刺激终止
First, propafenone immediate effect of intravenous injection. Twelve (male 7, female 5) patients 12 to 58 years of age were enrolled in a randomized, double-blind, placebo-controlled conditional crossover study in 10 patients with typical WPW syndromes (10 patients) and occult additional patients (2 patients) Have a history of syncope and / or recurrent episodes of supraventricular arrhythmias and conventional antiarrhythmic drug therapy is ineffective. At least 5 half-lives of cardioreactive drugs were discontinued before the trial, with the exception of 1 patient continuing with amiodarone (200 mg / d). Intubation begins with an electrophysiological test that first induces a sustained supraventricular (tachycardia) rate followed by intravenous infusion of propafenone 2 mg / kg (or placebo) (within 10 minutes), termination of electrical stimulation if not effective