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作者归纳了消炎痛最近在临床上10个方面的新用途:(1)治疗门脉高压症:以50毫克/8小时给肝硬化病人服用,发现肝血流量减少22％,肝静脉压梯度下降7％,心搏出量减少9％,全身血管阻力增加17％。可能是当门脉高压时,前列腺素降低内脏动脉阻力和增加门脉血流量,消炎痛通过抑制前列腺素使内脏小动脉阻力增加,门脉血流量减少,门脉压力下降。(2)治疗急性胰腺炎:在常规治疗基础上给予消炎痛栓剂50毫克,2次/日,治疗7天,结果疼痛程度显著减轻。可能是该药通过对急性胰腺炎时腹
The authors summarize the recent 10 new uses of indomethacin in clinical practice: (1) Treatment of Portal Hypertension: taking liver cirrhosis patients at 50 mg / 8 hours and found a 22% decrease in hepatic blood flow and a decrease in hepatic venous pressure gradient 7%, cardiac output reduced by 9%, systemic vascular resistance increased by 17%. Possibly, prostaglandins reduce visceral arterial resistance and increase portal blood flow when portal hypertension occurs. Indomethacin decreases the resistance of visceral arterioles by inhibiting prostaglandins, decreases portal blood flow, and decreases portal pressure. (2) the treatment of acute pancreatitis: given conventional indomethacin suppositories 50 mg, 2 times / day for 7 days, resulting in a significant reduction in the degree of pain. Probably the drug is passed on the abdomen of acute pancreatitis