正常人脑组织中微量元素铁、锌含量的测定

• 作 者: 郭树光 刘玮琳 王彦峰 玉雅丽
• 机 构: 中国医科大学第二临床学院检验科!沈阳110003,中国医科大学第二临床学院检验科!沈阳110003,中国医科大学第二临床学院检验科!沈阳110003,沈阳市康平县妇幼保健站
• 出 处: 中国医科大学学报
• 发表日期: 1999年04期
• 关键词: 微量元素铁 人脑组织 神经系统疾病 估计范围 原子吸收 内囊前肢 参考数据 内囊后肢 磁共振诊断 消化罐

目的：探讨正常尸体脑组织中微量元素铁、锌含量。方法：采用原子吸收法，对１４ 例正常尸体脑组织中１２ 个定义区域解剖３０１ 块湿组织样品进行微量元素铁、锌含量的测定与分析。结果：灰质中平均铁含量为（８７６５±１５４０） ｐｐｍ ，明显高于白质中铁的含量（４９３９±９８０） ｐｐｍ ， Ｐ ＜ ００１；而灰质中平均锌含量为（１０２０６±６８２）ｐｐｍ ，与白质中锌含量（９８４６±３８１） ｐｐｍ 比较无明显差异， Ｐ＞ ００５。随年龄增加铁含量升高。在左右两半球相应脑区比较，铁、锌含量有极其显著的正相关。脑组织不同部位铁含量差别很大，而锌含量差别不大。结论：所得结果可以看作是正常值估计范围，为研究人神经系统微量元素铁、锌含量与神经系统疾病的关系，提供参考数据。

Objective: To investigate the contents of trace elements iron and zinc in normal cadaver brain tissue. Methods: The contents of trace elements iron and zinc in 301 wet tissue samples were dissected in 12 defined regions of 14 normal cadaver tissues by atomic absorption spectrometry. Results: The average iron content in gray matter was (8765 ± 1540) ppm, which was significantly higher than that in white matter (4939 ± 980) ppm, P <001. The average zinc content in gray matter was (10206 ± 682) ppm, which showed no significant difference from that of white matter (9846 ± 381) ppm, P> 005. Iron content increases with age. In the left and right hemispheres corresponding brain areas, iron, zinc content has a very significant positive correlation. Different parts of brain tissue iron content vary greatly, while the zinc content difference is not big. CONCLUSION: The results obtained can be regarded as the normal range of estimation, and provide reference data for studying the relationship between iron and zinc contents of human nervous system and nervous system diseases.