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急性肾功能衰竭(ARF)最终都有肾血流动力学的改变。大量实验研究和临床观察都表明ARF与肾血流动力学的较大改变有关。对ARF时肾血流改变原因的研究,近十多年来已经取得很大进展,归纳起来有: 1.交感神经及儿茶酚胺的血管收缩作用。 2.肾素——血管紧张素系统的激活。 3.肾脏前列腺素(PG)E_2、I_2及血栓素A_2(TXA_2)的生成异常。 4.肾小管肾小球的反馈作用。 5.肾血流自身调节的丧失。 6.肾内弥漫性血管内凝血。 7.肾细胞(包括肾血管内皮细胞)肿胀。 8.肾小球超滤系数降低。本文拟就PG在ARF中的作用作一综述。
Acute renal failure (ARF) eventually has a change in renal hemodynamics. A large number of experimental studies and clinical observations have shown that ARF and renal hemodynamic changes. Research on the causes of ARF renal blood flow changes, the past 10 years has made great progress, summed up as follows: 1. Sympathetic nerve and catecholamines vasoconstriction. 2. Renin - angiotensin system activation. The abnormalities of renal prostaglandin (PG) E_2, I_2 and thromboxane A_2 (TXA_2) production. 4. Renal tubular glomerular feedback. 5. The loss of renal blood flow self-regulation. 6. Renal disseminated intravascular coagulation. 7. Renal cells (including renal vascular endothelial cells) swelling. 8. Glomerular filtration coefficient decreased. This article intends to review the role of PG in ARF.