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目的探讨类风湿性关节炎(RA)中青年组与老年组的临床特征。方法对69例17~60岁中青年与51例60岁以上的老年患者的临床资料进行比对分析。结果老年组以心血管病变、胃肠受累、骨关节炎、肺间质病变多见,与中青年组比较差异有统计学意义(P<0.05);与中青年组比较,老年组中血清C反应蛋白(CRP)显著升高[(33.1±21.2)mg/L vs(61.0±20.3)mg/L],而类风湿因子(RF)(75.3%vs 37.3%)与抗环瓜氨酸肽抗体(抗CCP抗体)阳性率(59.4%vs 35.2%)降低,差异均有统计学意义(P<0.05)。结论老年组的关节病变与合并疾病所占比例明显高于中青组,且老年组RA并发症类型、发病机制与中青年显著不同。
Objective To investigate the clinical features of rheumatoid arthritis (RA) young and old group. Methods The clinical data of 69 elderly patients aged 17-60 years and 51 elderly patients over the age of 60 were analyzed. Results The elderly group were more likely to have cardiovascular disease, gastrointestinal involvement, osteoarthritis and interstitial lung disease than those in the young group (P <0.05). Compared with the young group, the serum C (33.1 ± 21.2) mg / L vs (61.0 ± 20.3) mg / L], while the level of reactive protein (CRP) was significantly higher than that of anti-cyclic citrullinated peptide antibody (75.3% vs 37.3% (Anti-CCP antibody) positive rate (59.4% vs 35.2%), the difference was statistically significant (P <0.05). Conclusion The proportion of joint disease and comorbidity in the elderly group was significantly higher than that in the middle-aged and young-aged patients. The types and pathogenesis of RA in the elderly group were significantly different from those in middle-aged and young-aged patients.