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目的探讨采用血液灌流联合血液透析治疗尿毒症皮肤瘙痒患者的临床疗效。方法选取2012年5月至12月维持性血液透析的尿毒症皮肤瘙痒患者30例,其中每例患者均每月开展血液灌流联合血液透析治疗2次。详细观察并记录每例患者治疗前后的临床症状变化,并针对其结果进行回顾性对比分析。结果该组患者治疗后临床症状均较治疗前显著改善(P<0.05),其中明显缓解者9例,缓解者20例,治疗无效者1例。而所有患者治疗后经检查各项指标情况均显著优于治疗前,且各项对比差异结果均具有统计学意义(P<0.05)。结论采用血液灌流联合血液透析治疗尿毒症皮肤瘙痒临床疗效显著,不仅能显著缓解患者临床症状,对于其改善患者机能各项指标也有重要的作用。
Objective To investigate the clinical efficacy of hemoperfusion combined with hemodialysis in treating pruritus of uremic patients with skin pruritus. Methods Thirty patients with uremic pruritus who underwent maintenance hemodialysis from May 2012 to December 2012 were enrolled in this study. Each patient underwent hemoperfusion and hemodialysis twice a month. Detailed observation and record of each patient before and after treatment of clinical symptoms, and the results of a retrospective comparative analysis. Results The clinical symptoms of the patients in this group were significantly improved after treatment (P <0.05), of which 9 were significantly relieved, 20 were relieved, and 1 was ineffective. After treatment, all the indexes of the patients after treatment were significantly better than those before treatment, and the differences between the two groups were statistically significant (P <0.05). Conclusion Hemoperfusion combined with hemodialysis treatment of uremic skin pruritus significant clinical effect, not only can significantly alleviate the clinical symptoms of patients with its performance to improve various indicators also have an important role.