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树突状细胞(DC)是目前发现的功能最强的专职抗原提呈细胞(APC)。DC可来源于多种造血祖细胞,在不同外界信号刺激下分化为功能不同的DC,在这一过程中有多种信号通路的参与,其中蛋白激酶(PK)C-核因子(NF)-κB通路起到了重要作用,细胞因子、CD40等通过与其受体结合激活PKC,从而激活其下游的NF-κB通路,NF-κB发生核转位,启动不同基因的转录,相应调控不同的生理和病理反应。在NF-κB的各亚基中RelB对DC的分化最为关键。本文就DC分化过程中的不同信号通路,特别是PKC-NF-κB通路的作用进行综述。
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APC) found so far. DCs can be derived from a variety of hematopoietic progenitor cells and differentiate into DCs with different functions under different external signal stimuli. In this process, a variety of signaling pathways are involved. Among them, protein kinase (PK) C-nuclear factor (NF) κB pathway has played an important role, cytokines, CD40 and other receptors through its activation of PKC activation of its downstream NF-κB pathway, NF-κB nuclear translocation, start transcription of different genes, the corresponding regulation of different physiological and Pathological response. RelB is most critical for DC differentiation in each subunit of NF-κB. This review summarizes the roles of different signaling pathways in DC differentiation, specifically the PKC-NF-κB pathway.